Azithromycin CAS 83905-01-5
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CAS number ： 83905-01-5
molecular formula : C38H72N2O12
EINECS ： 617-500-5
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Email ： info@deshangchem.com
Mobile : +86-13153039501
TEL ： +86-531-88752665
CAS number：83905-01-5
molecular formula：C38H72N2O12
molecular weight：748.98
EINECS number：617-500-5
English synonyms
10% aqueous azithromycin;70% water-soluble azithromycin;Azithromycin 98%;N-METHYL-11-AZA-10-DEOXO-10-DIHYDROERYTHROMYCIN A;Azitromvcin;11-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-3,4,10-tr;11-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-2-ETHYL-3,4,10-TRIHYDROXY-14-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-3,5,6,8,10,12,13-HEPTAMETHYL-1-OXA-6-AZA-CYCLOPENTADECAN-15-ONE;9-DEOXO-9ALPHA-METHYL-9ALPHA-AZA-HOMOERYTHROMYCIN A
Related categories
Standard products; Chinese medicine reference substances; pharmaceutical intermediates; biochemical reagents; veterinary drugs; compounds: raw materials; antibiotics; reference substances; antibiotics; veterinary drugs; macrolactam antibiotics; drugs; raw materials; microbial metabolites; plant extracts Raw materials; small molecule inhibitors, natural products; pharmaceutical raw materials; organosilicon compounds; pharmaceutical raw materials; synthesis; veterinary raw materials; chemical industry; azithromycin; veterinary medicine, soluble powder, preparation; ;Pharmaceutical and Chemical Industry;Chemical Reagent;Reference Substance-Impurity Reference Substance;Medical Raw Materials;Pharmaceutical and Veterinary Drugs;Raw Material Intermediates-API;Other Chemical Products;API Raw Materials;Chemical Raw Materials-1;API API;Medical Raw Materials;Reference Substances - Chinese medicine reference substance; standard substance-traditional Chinese medicine standard substance; pharmaceutical, pesticide and dye intermediates; chemical raw materials; chemical raw materials; chemical intermediates-chemical raw materials; others; organic chemical raw materials; raw materials and intermediates; others; Belka Main products: daily chemicals; chemical reagents; general biochemical reagents-antibiotics; imported raw materials; industrialization; biological buffer series;
Antibiotics;Antibiotic;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;NeatsMore...Close...;1694 Pharmaceuticals&Personal Care Products;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-F Antibiotics; with Protein Synthesis Antibiotics;MacrolidesEPA;Mechanism of Action;Spectrum of Activity;API's;Inhibitors;83905-01-5
Introduction
Azithromycin is an antibiotic drug widely used in clinical practice. It has the advantages of broad antibacterial spectrum, less irritation to the gastrointestinal tract, and fast oral absorption. It is used by both adults and children. Azithromycin has less side effects than cephalosporin antibiotics, and is currently the most commonly used antibiotic drug for the treatment of bacterial infection-related diseases in hospitals in my country. This drug belongs to the second-generation semi-synthetic derivative of macrolides. Unlike erythromycin, it inserts a methyl group to replace the nitrogen at the 9a position of the erythromycin lactone ring, resulting in a 15-membered macrolide.
Chemical properties
| Melting point | 113-115°C |
| Specific optical rotation | D20 -37° (c = 1 in CHCl3) |
| Boiling point | 822.1±65.0 °C(Predicted) |
Density | 1.18±0.1 g/cm3(Predicted) |
| Storage conditions | Sealed in dry,2-8°C |
| Solubility | Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride. |
| Acidity coefficient(pKa) | pKa 8.74 (H2O t=25 I=0.167) (Uncertain);9.45(H2O t=25 I=0.167) (Uncertain) |
| Shape | neat |
| Color | White to Off-White |
Optical activity | [α]/D 45±2°, c = 1% in ethanol |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS database | 83905-01-5(CAS DataBase Reference) |
Use
● Macrolide antibiotics, a 15-membered nitrogen-containing heterocyclic ring, have a similar antibacterial mechanism to erythromycin, but have a broader antibacterial spectrum. The antibacterial activity against Gram-positive bacteria is stronger, and the antibacterial activity against Gram-negative bacteria such as Haemophilus influenzae, Salmonella, Escherichia coli, Shigella, etc. is also stronger. And acid stable, good tolerance. It has a good therapeutic effect on respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases caused by sensitive strains.
● It is an antibiotic drug, used for various infections caused by sensitive bacteria, such as respiratory system infection, skin and soft tissue infection
● For respiratory infections, urinary tract infections, skin and soft tissue infections, and sexually transmitted diseases
Production method
● Using erythromycin A as raw material, after oximation, Beckmann rearrangement under the action of hydrochloric acid, dehydration, reduction and methylation can obtain azithromycin.
Azithromycin CAS 83905-01-5
CAS number：83905-01-5
molecular formula：C38H72N2O12
molecular weight：748.98
EINECS number：617-500-5
English synonyms
10% aqueous azithromycin;70% water-soluble azithromycin;Azithromycin 98%;N-METHYL-11-AZA-10-DEOXO-10-DIHYDROERYTHROMYCIN A;Azitromvcin;11-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-3,4,10-tr;11-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-2-ETHYL-3,4,10-TRIHYDROXY-14-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-3,5,6,8,10,12,13-HEPTAMETHYL-1-OXA-6-AZA-CYCLOPENTADECAN-15-ONE;9-DEOXO-9ALPHA-METHYL-9ALPHA-AZA-HOMOERYTHROMYCIN A
Related categories
Standard products; Chinese medicine reference substances; pharmaceutical intermediates; biochemical reagents; veterinary drugs; compounds: raw materials; antibiotics; reference substances; antibiotics; veterinary drugs; macrolactam antibiotics; drugs; raw materials; microbial metabolites; plant extracts Raw materials; small molecule inhibitors, natural products; pharmaceutical raw materials; organosilicon compounds; pharmaceutical raw materials; synthesis; veterinary raw materials; chemical industry; azithromycin; veterinary medicine, soluble powder, preparation; ;Pharmaceutical and Chemical Industry;Chemical Reagent;Reference Substance-Impurity Reference Substance;Medical Raw Materials;Pharmaceutical and Veterinary Drugs;Raw Material Intermediates-API;Other Chemical Products;API Raw Materials;Chemical Raw Materials-1;API API;Medical Raw Materials;Reference Substances - Chinese medicine reference substance; standard substance-traditional Chinese medicine standard substance; pharmaceutical, pesticide and dye intermediates; chemical raw materials; chemical raw materials; chemical intermediates-chemical raw materials; others; organic chemical raw materials; raw materials and intermediates; others; Belka Main products: daily chemicals; chemical reagents; general biochemical reagents-antibiotics; imported raw materials; industrialization; biological buffer series;
Antibiotics;Antibiotic;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;NeatsMore...Close...;1694 Pharmaceuticals&Personal Care Products;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-F Antibiotics; with Protein Synthesis Antibiotics;MacrolidesEPA;Mechanism of Action;Spectrum of Activity;API's;Inhibitors;83905-01-5
Introduction
Azithromycin is an antibiotic drug widely used in clinical practice. It has the advantages of broad antibacterial spectrum, less irritation to the gastrointestinal tract, and fast oral absorption. It is used by both adults and children. Azithromycin has less side effects than cephalosporin antibiotics, and is currently the most commonly used antibiotic drug for the treatment of bacterial infection-related diseases in hospitals in my country. This drug belongs to the second-generation semi-synthetic derivative of macrolides. Unlike erythromycin, it inserts a methyl group to replace the nitrogen at the 9a position of the erythromycin lactone ring, resulting in a 15-membered macrolide.
Chemical properties
| Melting point | 113-115°C |
| Specific optical rotation | D20 -37° (c = 1 in CHCl3) |
| Boiling point | 822.1±65.0 °C(Predicted) |
Density | 1.18±0.1 g/cm3(Predicted) |
| Storage conditions | Sealed in dry,2-8°C |
| Solubility | Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride. |
| Acidity coefficient(pKa) | pKa 8.74 (H2O t=25 I=0.167) (Uncertain);9.45(H2O t=25 I=0.167) (Uncertain) |
| Shape | neat |
| Color | White to Off-White |
Optical activity | [α]/D 45±2°, c = 1% in ethanol |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS database | 83905-01-5(CAS DataBase Reference) |
Use
● Macrolide antibiotics, a 15-membered nitrogen-containing heterocyclic ring, have a similar antibacterial mechanism to erythromycin, but have a broader antibacterial spectrum. The antibacterial activity against Gram-positive bacteria is stronger, and the antibacterial activity against Gram-negative bacteria such as Haemophilus influenzae, Salmonella, Escherichia coli, Shigella, etc. is also stronger. And acid stable, good tolerance. It has a good therapeutic effect on respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases caused by sensitive strains.
● It is an antibiotic drug, used for various infections caused by sensitive bacteria, such as respiratory system infection, skin and soft tissue infection
● For respiratory infections, urinary tract infections, skin and soft tissue infections, and sexually transmitted diseases
Production method
● Using erythromycin A as raw material, after oximation, Beckmann rearrangement under the action of hydrochloric acid, dehydration, reduction and methylation can obtain azithromycin.
Team Presentation
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