CAS number：69-72-7
molecular formula：C7H6O3
molecular weight：138.12
EINECS number：200-712-3

English synonyms

2-HYDROXYBENZOIC ACID;ACIDUM SALICYLICUM;ACETYLSALISYLIC ACID IMP C;ACETYLSALICYLIC ACID IMPURITY C;FEMA 3985;SALICYCLIC ACID;SALICYLIC ACID;RETARDER TSA

Related categories

Pesticide intermediates; Pesticide intermediates; Organophosphorus pesticides; Melting point standards; Organic acids; Antipyretic and analgesic; Disinfection and antiseptics; APIs; Carbonyl compounds; Pharmaceutical intermediates; Electroplating industry; body; pharmaceutical excipients; sour agents; inorganic salts; antioxidants; acidity regulators; impurity reference substances; cosmetic raw materials; nutritional fortifiers; general biochemical reagents - plant hormones; organic raw materials

Introduction

Salicylic acid is an important organic synthetic raw material and is widely used in medicine, pesticide, rubber, dye, food and fragrance industries. In the pharmaceutical industry, the main drugs used in the production of salicylic acid are sodium salicylate, oil of wintergreen (methyl salicylate), aspirin (acetylsalicylic acid), salicylic acid amine, benzene salicylate esters, etc. In the dye industry, it is used to produce mordant pure yellow, direct yellow 3GN, direct yellow GR, direct brown 3GN, acid mordant brown G, acid mordant yellow GG, acid complex yellow and other dyes. In the production of pesticides, salicylic acid is used to synthesize the intermediates of the organophosphorus insecticides amphos, isopropyl salicylate, and the intermediates of the rodenticides warfarin and coumate4 -Hydroxycoumarin. In the rubber industry, it is used as an anti-scorch agent and in the production of ultraviolet absorbers and foaming agents. Fragrance raw materials, preparation of methyl salicylate, ethyl salicylate, etc.; food preservatives, mostly its sodium salt, which is now banned in some countries; methyl salicylate can be used as oral cleaners, such as toothpaste spices.

Use

●  Salicylic acid, also known as o-hydroxybenzoic acid, is an important raw material for organic synthesis. In the production of pesticides, it is used to synthesize isopropyl salicylate, an intermediate of the organophosphorus insecticides amphophos and methyl isoflophos, and 4-hydroxyl alkaloid, an intermediate of the rodenticides warfarin and coumate In the pharmaceutical industry, salicylic acid is not only used as a disinfectant and antiseptic, but also as an intermediate of various drugs such as acetylsalicylic acid (aspirin); it is also an important raw material for dyes, spices, rubber and other industries.

●  It is mainly used as the raw material of aspirin medicine and the raw material of pesticide ammonium phosphine, etc. It can also be used in dye industry, refined chemical reagent, etc.

●  The pharmaceutical industry is used to make antipyretic, analgesic, anti-inflammatory, diuretic and other drugs, and the dye industry is used to make azo direct dyes and acid mordant dyes, as well as spices, etc.

●  Used as complexation indicator and preservative

●  Salicylic acid is an important raw material for fine chemicals such as medicines, fragrances, dyes, and rubber auxiliaries. In the pharmaceutical industry, salicylic acid itself is used as a disinfectant and antiseptic for local keratin hyperplasia and skin fungal infection. As a pharmaceutical intermediate, used in Zhitongling, diurea, acetylsalicylic acid (aspirin), sodium salicylate, salicylic amide, euglycylate, niclosamide, phenyl salicylate, ethylparaben Production of drugs such as esters, bismuth subsalicylate, and sulfasalazine. In the dye industry, it is used to produce direct yellow GR, direct light fast gray BL, direct light fast brown RT, acid medium brown G, acid medium yellow GG and other dyes. Various esters of salicylic acid can be used as flavorings, for example, methyl salicylate can be used as oral flavorings such as toothpaste, other flavoring flavors and food flavorings. In the rubber industry, it is used to produce anti-scorch agents, ultraviolet absorbers and foaming aids. Salicylic acid can also be used as phenolic resin curing agent, pulp preservative in textile printing and dyeing, bulking agent (dye accelerator) in synthetic fiber dyeing, etc.

●  Verify aluminum, boron, cerium, copper, iron, lead, manganese, mercury, nickel, silver, titanium, tungsten, vanadium, hyposulfite, nitrate and nitrite. Determination of aluminum, copper, iron, thorium, titanium and uranium. Standard for alkaline and iodometric titrations. Fluorescent indicator. Complexation indicator.

●  Determination of aluminum, boron, cerium, copper, iron, lead, manganese, mercury, silver, titanium, tungsten, vanadium, hyposulfite, nitrate and nitrite. Precipitating thorium separates thorium from cerium and other rare earth elements, and separates zirconium from titanium. Fluorescent indicator; preservative; complex indicator.

●  Anti-inflammatory inhibitors of cyclooxygenase activity. Determination of aluminum, boron, cerium, copper, iron, lead, manganese, mercury, silver, titanium, tungsten, vanadium, hyposulfite, nitrate and nitrite. Precipitating thorium separates thorium from cerium and other rare earth elements, separates zirconium and titanium, fluorescent indicator, preservative, and complex indicator.

Production method

●  Phenol reacts with sodium hydroxide to generate sodium phenolate, after distillation and dehydration, carbon dioxide is passed through for carboxylation to obtain sodium salicylate, which is acidified with sulfuric acid to obtain crude product. The crude product is refined by sublimation to obtain the finished product. Raw material consumption quota: phenol (98%) 704kg/t, caustic soda (95%) 417kg/t, sulfuric acid (95%) 500kg/t, carbon dioxide (99%) 467kg/t.

●  The preparation method is obtained by carboxylation of sodium phenolate with carbon dioxide and then acidification.
Use phenol and liquid caustic soda to make phenol sodium salt solution, vacuum dry, then slowly feed dry carbon dioxide at 100 ° C, when the pressure reaches 0.7 ~ 0.8MPa, stop passing carbon dioxide, and heat up to 140 ~ 180 ° C. After the reaction is completed, add clean water to dissolve the sodium salicylate, decolorize and filter, and then add sulfuric acid for acidification, that is, salicylic acid is precipitated, and the finished product is obtained after filtration, washing and drying.

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