CAS number：67-20-9
molecular formula：C8H6N4O5
molecular weight：238.16
EINECS number：200-646-5

English synonyms

1-(((5-nitro-2-furanyl)methylene)amino)-2,4-imidazolidinedione;1-(5-NITRO-2-FURFURYLIDENEAMINO)HYDANTOIN;1-[(5-nitrofurfurylidene)amino]hydantoin;LABOTEST-BB LT00134625;FURADOXYL;N-(5-NITRO-2-FURFURYLIDENE)-1-AMINOHYDANTOIN;NITROFURANTOIN;NITROFURANTOINE

Related categories

Intermediates; Chemical Products-Organic Chemicals; Reference Substances; Raw Materials Intermediates-APIs; Furans; Nitrofurans and Metabolites; Analytical Standards; Enzymes; Antibiotics; Furans; Small Molecule Inhibitors; Pharmaceutical Raw Materials ;Antibiotics;Life Science Standard Products;Antibacterial Drugs;Biochemical Reagents;Pharmaceutical Raw Materials-Research Raw Materials;Chemical Reagents;Organic Chemical Raw Materials;APIs;Medical Raw Materials;Synthetic Antimicrobials;Large Chemicals;Pharmaceutical Raw Materials;Chemical Materials;Additives 1;Anti-inflammatory;General Biochemical Reagents-Antibiotics;Chemical Reagents;Control Substances;Furan&Benzofuran;Peptide Synthesis/Antibiotics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;antibiotic

Introduction

Nitrofurantoin, also known as nitrofurantoin, nitrofuranidine, nitrofurantoin, nitronitrofurantoin, chemical name 1-[[(5-nitro-2-furanyl)methylene]amino]-24-imidazolidinedioe, is a synthetic antibacterial drug It has a broad antibacterial spectrum and has antibacterial effects on most Gram-positive and negative bacteria, such as Staphylococcus aureus, Escherichia coli, Staphylococcus albus and Streptococcus pyogenes. Clinically, it is commonly used for urinary tract infections caused by sensitive bacteria, such as pyelonephritis and urinary tract infections. cystitis and prostatitis.

Chemical properties

Orange-yellow needle crystals. Melting point 270-272 ° C (decomposition). The number of milligrams soluble in 100ml of the following solvents: water 19.0, 95% ethanol 51.0, acetone 510, DMF8000. Almost insoluble in chloroform. When exposed to light, the color becomes darker, odorless, and tastes bitter. 

Use

●  This product is an excellent antibacterial drug. It absorbs rapidly and completely after oral administration, and excretes quickly. The excretion in urine can reach 40-50%. It is often used to treat urinary tract infections caused by various sensitive bacteria. Acute urinary tract infection caused by Bacillus has good curative effect.

●  It is an excellent antibacterial drug with a wide antibacterial spectrum and is suitable for urinary tract infections such as pyelonephritis, pyelitis and cystitis.

Production method

●  Semicarbazide is produced by condensation of hydrazine hydrate and urea, and then acetone semicarbazide is obtained by condensation with acetone. Then acetone hydantoin is synthesized with ethyl chloroacetate, and nitrofurantoin is obtained by condensation with 5-nitrofurfural diacetate after hydrolysis.

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