CAS number：67-97-0
molecular formula：C27H44O
molecular weight：384.64
EINECS number：200-673-2

English synonyms

Vitamin D3 solution;Vitamin D3-d3 Cholecalciferol (6,19,19-d3);Cholecalciferol d6;Vitamin D3-d6;10-Secocholesta-5,7,10(19)-trien-;(5Z,7E,3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol;3Z-[2E-[(1R,3aS,7aR)-1S-[1R,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol;(+)-VITAMIN D/3, CRYSTALLINE, 99+%

Related categories

Pharmaceutical APIs; Agricultural and Environmental Standards; Vitamins; Food Additives; Nutritional Enhancers; Small Molecule Inhibitors, Natural Products; Feed Additives; Vitamin Additives; Pharmaceutical Raw Materials; Standards; Analytical Standards; Vitamins; Plant Extracts; Raw materials; Small molecule inhibitors; Food additive raw materials; Industrial raw materials; Nutrients; Nutritional supplements; Biochemical reagents; Chemical raw materials; Medical raw materials; Vitamin series; Food and feed additives; DROMOS; Other pharmaceuticals; APIs; Reagents; Flavors and fragrances ;Reference substance-Chinese medicine reference substance;Food and feed additive;Standard substance-Chinese medicine standard substance;API;Biochemical reagent-vitamin;Food and feed additive;New product;Regulator;Aromatic hydrocarbon;Fine chemical industry;Chinese medicine reference substance;Additive;Organic chemical industry Raw materials; content products; organic chemicals; impurity reference substances; chemical product catalog - raw materials; medical raw materials; chemical intermediates; daily chemicals; general biochemical reagents - lipids; chemical reagents; Detection of standard substances;Sterol series;Miscellaneous Natural Products;Vitamin D3 analogs;Vitamins - Deuterated;Nutritional Supplements;Vitamins and derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Vitamin Ingredients;Miscellaneous Compounds;Vitamins series;Other APIs;Inhibit

Introduction

Vitamin D3, also known as cholecalciferol, is a type of vitamin D that has been proven to be the true active form of vitamin D in the body. There are at least 10 known types of vitamin D, but the most important are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Cholecalciferol, also known as vitamin D3, is the most important form of vitamin D family. It mainly regulates the metabolism of calcium and phosphorus in the body. Vitamin D3 is transformed from 7-dehydrocholesterol in the skin by ultraviolet radiation.

Chemical properties

White columnar crystal or crystalline powder, odorless and tasteless. Melting point 84～88℃, specific optical rotation αD20=+105°～+112°. Very soluble in chloroform, easily soluble in ethanol, ether, cyclohexane and acetone, slightly soluble in vegetable oil, insoluble in water. Good heat resistance, but unstable to light, easy to oxidize in air. Rat oral LD1042mg/kg. 

Use

●  Vitamin D3 can maintain the normal metabolism of calcium and phosphorus, and can promote the body's absorption of calcium and phosphorus. When it is deficient, children are prone to rickets. my country stipulates that it can be used to fortify margarine, and the usage amount is 125-156 μg/kg; the usage amount in fortified dairy products is 63-125 μg/kg; the usage amount in fortified infant food is 50-100 μg/kg; in fortified milk and The amount used in milk drinks is 10-40μg/kg; the maximum amount used in fortified solid drinks and ice cream is 10-20μg/kg
.
●  Vitamin D3 can maintain the normal metabolism of calcium and phosphorus, and promote the body's absorption of calcium and phosphorus. Pigs have the same utilization rate of vitamin D2 and D3, but poultry's utilization rate of vitamin D2 is only 1/40-1/30 of D3. When vitamin D3 is deficient, the eggshell becomes thinner, the egg production rate decreases, and rickets occurs. The dosage is 1000-1500IU/kg.

●  Vitamin D is a fat-soluble vitamin. There are more than a dozen compounds known to have the effect of vitamin D, and there are no steroid derivatives, among which vitamin D2 and vitamin D3 are of great practical significance. The world is dominated by D3, and the "international standard substance" of vitamin D is also the pure crystal of D3. The main function of vitamin D is the metabolism of calcium and phosphorus, and it is difficult to promote calcium and phosphorus absorption and bone calcification. When the human body lacks D, the ability to absorb calcium and phosphorus decreases, and the levels of calcium and phosphorus in the blood decrease, so that calcium and phosphorus cannot be deposited in bone tissue, and even bone salt will dissolve, hindering bone calcification. Children who lack it will get rickets, and adults will get osteomalacia. Japan mainly produces and uses D2. Among various demands, medicines account for 30%, feed additives account for 65%, and food additives account for 5%. According to the "Hygienic Standards for the Use of Food Nutritional Fortifiers (1993)" promulgated by the Ministry of Health of my country, D2 and D3 as nutritional supplements can be used in liquid milk, margarine, dairy products and infant food.

●  Mainly used in food, health products and other related products

●  Vitamin D3 acts through the receptor, which is a member of the ligand-dependent transcription factor family, regulates the proliferation and differentiation of normal cells and cancer cells, and has anti-proliferation and anti-proliferative effects on breast cancer, colon cancer and prostate cancer. transfer effect. Activated vitamin D receptors in the intestine and bone also maintain calcium absorption and homeostasis.

●  Vitamin medicine, which mainly promotes the absorption and deposition of calcium and phosphorus in the intestines, and is used for the treatment of rickets and osteomalacia

Production method

●  Dissolve 7-dehydrocholesterol in ethanol, irradiate with ultraviolet light to open the ring, concentrate the reaction liquid, freeze, filter, pass the filtrate through nitrogen and concentrate to dryness under reduced pressure to obtain crude vitamin D3 liquid. And then refined to obtain vitamin D3.

●  Vitamin D3 naturally exists in liver, milk and egg yolk. The industrial production method is to extract 7-dehydrocholesterol that cannot be absorbed by the human body from vegetable oil or yeast, then dissolve it in chloroform or cyclohexane, and then dissolve it in quartz glass. The flask was converted into vitamin D3 by ultraviolet irradiation.

●  Vitamin D3 naturally exists in liver, milk and egg yolk. The industrial production method is to extract 7-dehydrocholesterol that cannot be absorbed by the human body from vegetable oil or yeast, and then dissolve it in chloroform or cyclohexane, and then put it on quartz glass. The flask was converted into vitamin D3 by ultraviolet irradiation.

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