CAS number：54965-21-8
molecular formula：C12H15N3O2S
molecular weight：265.33
EINECS number：259-414-7

English synonyms

[5-(PROPYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMICACID,METHYLESTER;[5-(PROPYLTHIO)BENZIMIDAZOL-2-YL]CARBAMICACIDMETHYLESTChemicalbookER;(5-PROPYLSULFANYL-1H-BENZOIMIDAZOL-2-YL)-CARBAMICACIDMETHYLESTER;ALBAZINE;ALBEN;ALBENDAZOLE;ALBENZA;AKOSNCG1-0064

Related categories

Raw materials for veterinary use; intermediates; raw materials for veterinary drugs; raw materials; anthelmintic health care agents; feed additives; anti-parasitic drugs; drugs; benzimidazoles; pharmaceutical raw materials, intermediates, microbial pesticides; aromatic hydrocarbons; analytical standards; Raw materials; raw materials for agriculture, forestry, fishery and animal husbandry; pharmaceutical chemicals; other raw materials; aquaculture, feed processing raw materials; agricultural raw materials; veterinary raw materials - raw materials; raw materials intermediates - raw materials; ;Veterinary drug raw materials; chemical raw materials-APIs; veterinary drugs; anthelmintic drugs; pharmaceutical intermediates; antiparasitic drugs; imidazoles; small molecule inhibitors; pharmaceutical raw materials; pharmaceutical raw materials; forensic and veterinary standards; antibiotics; Compounds: raw materials; pharmaceutical broad-spectrum anthelmintics; other pharmaceuticals; Chinese medicine reference substances; medicinal raw materials; pharmaceutical veterinary drugs; medical raw materials-raw materials; agricultural veterinary raw materials; pesticides and veterinary drugs; chemicals; Intermediates;Vitamin drugs;Intermediates-chemical intermediates;Chemical intermediates;Chemicalbook intermediates in pharmaceuticals, pesticides and dyes;Additives;Chemical raw materials;Rounding roundworms, pinworms;Impurity reference substances;Organic chemical raw materials;Pharmaceutical;ActivePharmaceuticalIngredients ;API;Intermediates&FineChemicals;Pharmaceuticals;Veterinaries;MiscellaneousCompounds;Aromatics;Heterocycles;Sulfur&SeleniumCompounds;AnimalPharmaceuticals;Pharmaceuticalintermediate;OVRETTE;Vermifuge;Chemical;chemical reagents-veterinary raw materials;the company's main products;reagents;inorganic chemicals;chemical reagents;chemical raw materials; industrialization

Introduction

Albendazole was developed by SmithKline Beecham (the predecessor of GlaxoSmithKline). Growth and reproduction, by inhibiting the worm's intestinal tract or absorbing proteins in cells, resulting in the worm's inability to absorb the sugar that it depends on for survival, depleting the worm's endogenous glycogen, inhibiting the fumarate reductase system, and preventing the production of adenosine triphosphate , resulting in the inability of the worm to survive and reproduce, and eventually the Chemicalbook worm gradually died due to energy exhaustion. Albendazole has the effect of completely killing hookworm eggs and whipworm eggs and partially killing roundworm eggs. It can also kill and expel various nematodes parasitic in animals. and expulsion. Indicated for the treatment of hydatid (hydatid) and nervous system infections (cysticercosis) caused by threadworms in pork, also for the treatment of hookworms, roundworms, pinworms, trichinella, tapeworms, whipworms and roundworms Nematode disease.

 Chemical properties

Protibendazole is also called albendazole, white to pale yellow crystalline powder, odorless, melting point 208～210℃, insoluble in water, slightly soluble in hot dilute hydrochloric acid, acetone or chloroform, soluble in methanol, ethanol or acetic acid.

Slightly soluble in acetone or chloroform, insoluble in water, slightly soluble in hot dilute hydrochloric acid, soluble in methanol, ethanol, acetic acid, etc.

Use

●  As an anthelmintic, it is effective against animal gastrointestinal nematodes and liver flukes. Can be mixed with feed. Uses The high-efficiency broad-spectrum anthelmintic is one of the benzimidazoles with a broad anthelmintic spectrum and the strongest insecticidal effect. It is suitable for expelling roundworms, pinworms, hookworms, whipworms, treating various types of cysticercosis, and can also be used for deworming livestock.

●  For the control of cabbage downy mildew, rice blast, tobacco powdery mildew, anthracnose, etc.

●  Broad spectrum anthelmintic. Can be used to expel roundworms, pinworms, tapeworms, whipworms, etc.

●  This product is a high-efficiency, broad-spectrum anthelmintic new drug, which has significant efficacy against Fasciola hepatica, tapeworm, lung and gastrointestinal nematodes. It is one of the most powerful benzimidazoles, and is currently the first choice drug Chemicalbook for the prevention and treatment of parasitic diseases of livestock and poultry. The product is effective against Fasciola hepatica adults and larvae of cattle and sheep, and Fasciola hepatica, and the reduction rate can reach 90-100%. In recent years, it has been found that this product also has a strong effect on bovine cysticercosis. After treatment, the cysticercosis decreases and the lesions disappear. In addition, the product can also be used to prevent parasitic infection, so it can achieve good results in promoting sheep growth and increasing wool production.

●  High-efficiency broad-spectrum anthelmintic. It can block the worm's absorption of various nutrients and glucose, resulting in the depletion of the worm's glycogen, making the parasite unable to survive and reproduce. For the treatment of single or mixed infections caused by roundworms, pinworms, whipworms, hookworms, etc.

●  Binds tubulin and inhibits microtubule polymerization.

●  A benzimidazole broad-spectrum antiparasitic agent.

Production method

●  2-acetamido-4-chloronitrobenzene is used as the starting material, reacts with propanethiol to obtain 2-amino-4-propylthionitrobenzene, and is reduced by palladium carbon to obtain-2amino-4 - Propylthioaniline. Then, it is cyclized with methyl cyanamide to obtain propylthiobenzimidazole.

●   Take o-nitroaniline as the starting material, react with sodium thiocyanate to obtain 2-nitro-4-thiocyanoaniline, and then react with bromopropane to obtain 2-nitro-4-propylthio Aniline is reduced to 2-amino-4-propylthioaniline by sodium sulfide, without separation, and directly cyclized with methyl cyanamide to obtain propylthiobenzimidazole. The total yield is 60%.

●  Using carbendazim as raw material, react with sodium sulfide cyanate to obtain methyl cyano-benzimidazole-2-carbamate, and the yield is 90%. Then carry out a reduction reaction without separation, and directly condense it with bromopropane to obtain a yield of 94%. Or react carbendazim with cyanosulfonic acid to obtain 5-sulfonyl chloride-benzimidazole-2-carbamic acid methyl ester with a yield of 93%. Then use iron powder (zinc powder) to reduce to methyl 2-mercapto-2 benzimidazole-2-carbamate, and then react with bromopropane to obtain.

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