Cisatracurium besylate CAS 96946-42-8
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CAS number ： 96946-42-8
molecular formula : C53H72N2O12.2C6H5O3S
EINECS ： 620-579-9
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Email ： info@deshangchem.com
Mobile : +86-13153039501
TEL ： +86-531-88752665
English synonyms
(1r,1'r,2r,2'r)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate;cisatracurium besilate;cisatracurium besylate;Cisatracurium;1R-CIS,1R∧-CIS (CISATRACURIUM BESYLATE);Cisatrcurium Besylate;3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propionic acid 5-[3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl ester;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
Related categories
Pharmaceutical Raw Materials; Chemical Products-Organic Chemicals; Intermediates; APIs; Pharmaceutical APIs; Pharmaceutical Muscle Relaxants; Pharmaceutical Intermediates; Small Molecule Inhibitors; Neuromuscular Blocking Agent; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Other APIs ;Analgesic series;Analytical reagents-reference substances;Medical raw materials;Raw materials;Medicine, pesticide and dye intermediates;Chemical materials;Pharmaceutical raw materials;Impurity reference substances;Chemical reagents
Introduction
Cisatracurium besylate is the besylate form of atracurium. It is a synthetic non-depolarizing muscle relaxant. Its effect is similar to that of tubocurarine. The onset time is 1 minute and the duration for 15 minutes. Therapeutic dose does not affect heart, liver and kidney function. Not accumulative. In large doses, it can promote the release of histamine. For muscle relaxation or breathing control required for surgery. Compared with the current main clinical muscle relaxant anesthetics, atracurium besylate has the characteristics of metabolism through non-hepatic and non-renal pathways and cardiovascular stability. The muscle relaxation effect is 3 times stronger than that of atracurium, and it has no cardiovascular side effects. Cisatracurium besylate is mainly suitable for general anesthesia, and can be widely used in endotracheal intubation, liver and kidney dysfunction, cardiovascular surgery and elderly and pediatric patients.
Chemical properties
| Melting point | 90-93°C |
| Storage conditions | Sealed in dry,Store in freezer, under -20°C |
Solubility | H2O: soluble1mg/mL |
| Color | white |
Use
Active Pharmaceutical Ingredients
API, also known as active pharmaceutical ingredients, refers to any substance or mixture of substances used in the manufacture of drugs. Such substances are used in the diagnosis, treatment, symptom relief, treatment or prevention of diseases. It has pharmacological activity or other direct effects or can affect the function or structure of the body. API meaning pharma.
Production method
API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug
Cisatracurium besylate CAS 96946-42-8
English synonyms
(1r,1'r,2r,2'r)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate;cisatracurium besilate;cisatracurium besylate;Cisatracurium;1R-CIS,1R∧-CIS (CISATRACURIUM BESYLATE);Cisatrcurium Besylate;3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propionic acid 5-[3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl ester;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
Related categories
Pharmaceutical Raw Materials; Chemical Products-Organic Chemicals; Intermediates; APIs; Pharmaceutical APIs; Pharmaceutical Muscle Relaxants; Pharmaceutical Intermediates; Small Molecule Inhibitors; Neuromuscular Blocking Agent; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Other APIs ;Analgesic series;Analytical reagents-reference substances;Medical raw materials;Raw materials;Medicine, pesticide and dye intermediates;Chemical materials;Pharmaceutical raw materials;Impurity reference substances;Chemical reagents
Introduction
Cisatracurium besylate is the besylate form of atracurium. It is a synthetic non-depolarizing muscle relaxant. Its effect is similar to that of tubocurarine. The onset time is 1 minute and the duration for 15 minutes. Therapeutic dose does not affect heart, liver and kidney function. Not accumulative. In large doses, it can promote the release of histamine. For muscle relaxation or breathing control required for surgery. Compared with the current main clinical muscle relaxant anesthetics, atracurium besylate has the characteristics of metabolism through non-hepatic and non-renal pathways and cardiovascular stability. The muscle relaxation effect is 3 times stronger than that of atracurium, and it has no cardiovascular side effects. Cisatracurium besylate is mainly suitable for general anesthesia, and can be widely used in endotracheal intubation, liver and kidney dysfunction, cardiovascular surgery and elderly and pediatric patients.
Chemical properties
| Melting point | 90-93°C |
| Storage conditions | Sealed in dry,Store in freezer, under -20°C |
Solubility | H2O: soluble1mg/mL |
| Color | white |
Use
Active Pharmaceutical Ingredients
API, also known as active pharmaceutical ingredients, refers to any substance or mixture of substances used in the manufacture of drugs. Such substances are used in the diagnosis, treatment, symptom relief, treatment or prevention of diseases. It has pharmacological activity or other direct effects or can affect the function or structure of the body. API meaning pharma.
Production method
API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug
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