Deshang Chemical
Deshang Chemical
Deshang Chemical
FASUDIL CAS 103745-39-7

FASUDIL CAS 103745-39-7

FASUDIL CAS 103745-39-7

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CAS number : 103745-39-7


molecular formula : C14H17N3O2S


EINECS : 816-154-4


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Email : info@deshangchem.com


Mobile : +86-13153039501


TEL : +86-531-88752665


Product details

CAS number:103745-39-7
molecular formula:C14H17N3O2S
molecular weight:291.37
EINECS number:816-154-4

English synonyms

Fasudil Hydrochloride Injection;5-(AZEPAN-4-YLSULFONYL)ISOQUINOLINE DIHYDROCHLORIDE;Fasudil HCI;5-(1,4-diazepan-4-ium-1-ylsulfonyl)isoquinoline;Fasudil Hydrchloride;1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE;at877;hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine

Related categories

Anti-anginal drugs; cardiovascular and cerebrovascular drugs; drugs; raw materials; small molecule inhibitors; quaternary ammonium salts, phase transfer catalysts Phase Transfer Catalysts; ;Signalling;Angiogenesis and Metastasis;Intracellular signaling;APIs;ERIL;Pharmaceutical APIs;APIs

Introduction

A drug called fasudil effectively blocks the feedback loop, protecting synapses and memory in animal models of Alzheimer's, while reducing the amount of beta-amyloid in the brain, researchers say. I hope that the research will enter the clinical stage as soon as possible, and that Alzheimer's disease will be completely extinct in our generation.

Chemical properties

Boiling point

506.2±60.0 °C(Predicted)

Density

1.289±0.06 g/cm3(Predicted)

Storage conditions

Store at RT

Solubility

H2O: >200 mg/mL

Shape

solid

Acidity coefficient(pKa)

9.73±0.20(Predicted)

Color

white

Water solubility

Soluble in water or DMSO

CAS database

103745-39-7(CAS DataBase Reference)

Fasudil Hydrochloride: C14H17N3O2S?HCl. [105628-07-7]. It crystallizes from water with a melting point of 220.5°C. White crystalline powder, melting point 219.3°C. The solubility in water can reach 2×10-2mol/L when Ph=5.0~7.0. Acute toxicity LD50 mice, rats (mg/kg): 67.5, 59.9 intravenous injection; 124.5, 123.2 subcutaneous injection; 273.9, 335.0 oral administration.

Use

●  Calcium antagonists. For vasospasm after subarachnoid hemorrhage surgery, it can also be used for neuroprotection, acute cerebral arterial embolism, chronic cerebral infarction and angina pectoris.

Production method

●  Isoquinoline is sulfonated by oleum, and the generated sulfonic acid is converted into sulfonyl chloride, and then reacted with diazepam to obtain the product.

FASUDIL CAS 103745-39-7

FASUDIL CAS 103745-39-7

FASUDIL CAS 103745-39-7

CAS number : 103745-39-7


molecular formula : C14H17N3O2S


EINECS : 816-154-4


——————


Email : info@deshangchem.com


Mobile : +86-13153039501


TEL : +86-531-88752665


Product details

CAS number:103745-39-7
molecular formula:C14H17N3O2S
molecular weight:291.37
EINECS number:816-154-4

English synonyms

Fasudil Hydrochloride Injection;5-(AZEPAN-4-YLSULFONYL)ISOQUINOLINE DIHYDROCHLORIDE;Fasudil HCI;5-(1,4-diazepan-4-ium-1-ylsulfonyl)isoquinoline;Fasudil Hydrchloride;1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE;at877;hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine

Related categories

Anti-anginal drugs; cardiovascular and cerebrovascular drugs; drugs; raw materials; small molecule inhibitors; quaternary ammonium salts, phase transfer catalysts Phase Transfer Catalysts; ;Signalling;Angiogenesis and Metastasis;Intracellular signaling;APIs;ERIL;Pharmaceutical APIs;APIs

Introduction

A drug called fasudil effectively blocks the feedback loop, protecting synapses and memory in animal models of Alzheimer's, while reducing the amount of beta-amyloid in the brain, researchers say. I hope that the research will enter the clinical stage as soon as possible, and that Alzheimer's disease will be completely extinct in our generation.

Chemical properties

Boiling point

506.2±60.0 °C(Predicted)

Density

1.289±0.06 g/cm3(Predicted)

Storage conditions

Store at RT

Solubility

H2O: >200 mg/mL

Shape

solid

Acidity coefficient(pKa)

9.73±0.20(Predicted)

Color

white

Water solubility

Soluble in water or DMSO

CAS database

103745-39-7(CAS DataBase Reference)

Fasudil Hydrochloride: C14H17N3O2S?HCl. [105628-07-7]. It crystallizes from water with a melting point of 220.5°C. White crystalline powder, melting point 219.3°C. The solubility in water can reach 2×10-2mol/L when Ph=5.0~7.0. Acute toxicity LD50 mice, rats (mg/kg): 67.5, 59.9 intravenous injection; 124.5, 123.2 subcutaneous injection; 273.9, 335.0 oral administration.

Use

●  Calcium antagonists. For vasospasm after subarachnoid hemorrhage surgery, it can also be used for neuroprotection, acute cerebral arterial embolism, chronic cerebral infarction and angina pectoris.

Production method

●  Isoquinoline is sulfonated by oleum, and the generated sulfonic acid is converted into sulfonyl chloride, and then reacted with diazepam to obtain the product.

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