Lenalidomide CAS 191732-72-6
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CAS number ： 191732-72-6
molecular formula : C13H13N3O3
EINECS ： 691-297-1
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Email ： info@deshangchem.com
Mobile : +86-13153039501
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CAS number：191732-72-6
molecular formula：C13H13N3O3
molecular weight：259.26
EINECS number：691-297-1
English synonyms
enalidomide;Lenalidomid;Revlimid;3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione,Lenalidomide;LenalidoMide(CC-5013,RevliMid);Lenalidomide ,98%;3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;(3S)-3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
Related categories
Pharmaceutical raw materials; acid halides; anticancer drugs; treatment of chronic myeloma; piperidine; indole; antitumor; medical raw materials; scientific research reagents; cell signaling pathway inhibitors; pharmaceutical intermediates; cell apoptosis; raw materials; medicine Raw materials; intermediates; small molecule inhibitors; small molecule inhibitors, natural products; reference substances - impurity reference substances; medical raw materials; cell biology reagents; pharmaceutical impurities and intermediates; raw materials; pharmaceutical, pesticide and dye intermediates; raw materials Medicine-API;Molecular Targeted Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles;Inhibitor;CC-5013;Inhibitors;pharmaceutical intermediate;API;Chemical raw material;Impurity reference substance;API and intermediate;Chemical reagent;Scientific research raw material ;other products
Introduction
In the past decade, lenalidomide (also known as lenalidomide) has been successfully used to treat inflammatory diseases and cancer, and the FDA approved indications are: combined with dexamethasone for the treatment of multiple myeloma (MM ); as maintenance therapy for MM after autologous hematopoietic stem cell transplantation. However, what many patients and friends do not know is that it can also be used in hepatocellular carcinoma.
Chemical properties
Melting point | 265-268 °C |
Boiling point | 614.0±55.0 °C(Predicted) |
| Density | 1.460±0.06 g/cm3(Predicted) |
| Storage conditions | 2-8°C |
Solubility | Soluble in DMSO (up to 30 mg/ml) |
| Shape | solid |
| Acidity coefficient(pKa) | 10.75±0.40(Predicted) |
| Color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS database | 191732-72-6(CAS DataBase Reference) |
Use
● Lenalidomide is an immunomodulatory drug with multiple mechanisms of action. In vitro studies, lenalidomide has three main effects: 1) direct anti-tumor effect 2) inhibition of angiogenesis 3) immune regulation . In vivo, lenalidomide directly or indirectly induces tumor cell apoptosis by inhibiting bone marrow stromal cell support, antiangiogenic and antiosteoclastic effects, and immunomodulatory activities. At the molecular level, lenalidomide has been shown to interact with ubiquitin E3 ligase and target this enzyme to degrade the Ikaros transcription factors IKZF1 and IKZF3.
Production method
API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug
Lenalidomide CAS 191732-72-6
CAS number：191732-72-6
molecular formula：C13H13N3O3
molecular weight：259.26
EINECS number：691-297-1
English synonyms
enalidomide;Lenalidomid;Revlimid;3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione,Lenalidomide;LenalidoMide(CC-5013,RevliMid);Lenalidomide ,98%;3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;(3S)-3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
Related categories
Pharmaceutical raw materials; acid halides; anticancer drugs; treatment of chronic myeloma; piperidine; indole; antitumor; medical raw materials; scientific research reagents; cell signaling pathway inhibitors; pharmaceutical intermediates; cell apoptosis; raw materials; medicine Raw materials; intermediates; small molecule inhibitors; small molecule inhibitors, natural products; reference substances - impurity reference substances; medical raw materials; cell biology reagents; pharmaceutical impurities and intermediates; raw materials; pharmaceutical, pesticide and dye intermediates; raw materials Medicine-API;Molecular Targeted Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles;Inhibitor;CC-5013;Inhibitors;pharmaceutical intermediate;API;Chemical raw material;Impurity reference substance;API and intermediate;Chemical reagent;Scientific research raw material ;other products
Introduction
In the past decade, lenalidomide (also known as lenalidomide) has been successfully used to treat inflammatory diseases and cancer, and the FDA approved indications are: combined with dexamethasone for the treatment of multiple myeloma (MM ); as maintenance therapy for MM after autologous hematopoietic stem cell transplantation. However, what many patients and friends do not know is that it can also be used in hepatocellular carcinoma.
Chemical properties
Melting point | 265-268 °C |
Boiling point | 614.0±55.0 °C(Predicted) |
| Density | 1.460±0.06 g/cm3(Predicted) |
| Storage conditions | 2-8°C |
Solubility | Soluble in DMSO (up to 30 mg/ml) |
| Shape | solid |
| Acidity coefficient(pKa) | 10.75±0.40(Predicted) |
| Color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS database | 191732-72-6(CAS DataBase Reference) |
Use
● Lenalidomide is an immunomodulatory drug with multiple mechanisms of action. In vitro studies, lenalidomide has three main effects: 1) direct anti-tumor effect 2) inhibition of angiogenesis 3) immune regulation . In vivo, lenalidomide directly or indirectly induces tumor cell apoptosis by inhibiting bone marrow stromal cell support, antiangiogenic and antiosteoclastic effects, and immunomodulatory activities. At the molecular level, lenalidomide has been shown to interact with ubiquitin E3 ligase and target this enzyme to degrade the Ikaros transcription factors IKZF1 and IKZF3.
Production method
API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug
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