Product name: Di-tert-butyl dicarbonate

CAS: 24424-99-5

Molecular formula: C10H18O5

EINECS: 246-240-1

English synonyms

(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, solid/liquid

Introduction

BOC anhydride is an organic compound with the molecular formula C10H18O5. It is used to introduce tert-butyloxycarbonyl protecting groups in organic synthesis, especially for protecting the amino group of amino acids.

Applications

Di-Tert-Butyl Dicarbonate Is a Carboxylic Acid Ester Derivative That Can Be Widely Used in the Synthesis of Medicine, Protein and Peptide Synthesis, Biochemical Food, Cosmetics and Other Products.

Chemical Properties

Boc Anhydride Is a Flammable Liquid. Melting Point 23°c, Boiling Point 56-57°c (6.55e-2kpa).

Reference Quality Standards

Appearance: Low Melting Point Crystalline Solid Purity (Hplc) ≥99.0%
Melting Point: 23 °c (Lit.)
Boiling Point: 65-67 °c
Refractive Index: N20/D 1.409 (Lit.)
Drying Loss: ≤0.5%

Uses

1. Used as an intermediate for pharmaceutical and organic synthesis, it is an important amino protecting agent used in the synthesis of pharmaceutical and agrochemical products
2. Used to introduce tert-butyloxycarbonyl protecting groups in organic synthesis.
3. Di-tert-butyl dicarbonate (Boc anhydride) is used to introduce tert-butyloxycarbonyl protecting groups in organic synthesis, especially for amino acid protection. It is widely used in the synthesis of various products such as pharmaceuticals, protein and peptide synthesis, biochemical food, cosmetics, etc.
4. Amino acid BOC reagent. Used to introduce tert-butyloxycarbonyl (BOC) protecting groups in organic synthesis, especially for amino acid protection. Tri-tert-butyloxycarbonyl protected hydrazine can be used to prepare fluorenylmethyloxycarbonyl ester in chromogenic reagents to monitor solid-phase aldehydes. Reagents used to prepare tert-butyloxycarbonyl protected amines. Reagents used to introduce tert-butyloxycarbonyl protecting groups. Alcohols such as tert-butyloxycarbonyl derivatives can be protected by Lewis acid catalysis. Aminomethylpropadiene, prepared by the reaction of tert-butyloxycarbonylaminopropyne with formaldehyde, diisopropylamine, and copper bromide, is a component of many bovine plasma amine oxidase inactivators.

Production Method

Potassium Tert-Butoxide Is Dissolved in Anhydrous Tetrahydrofuran, And Dry Carbon Dioxide Is Introduced at -5 to -20°c to Generate a Slurry. The Temperature Is Kept Low, And Phosgene Benzene Solution Is Added Dropwise to Obtain Di-Tert-Butyl Tricarbonate. It Is Dissolved in Carbon Tetrachloride, And an Appropriate Amount of 1,4-Diazabicyclo[2,2,2]octane Is Added. Stir at 25°c to Completely Release Carbon Dioxide and Convert It into Di-Tert-Butyl Dicarbonate.

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