CAS number：60-54-8
molecular formula：C22H24N2O8
molecular weight：444.43
EINECS number：200-481-9

English synonyms

12,12a-pentahydroxy-6-methyl-1,11-dioxo-1;4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-Naphthacenecarboxamide;4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-4-(dimethylamino)-4;6-methyl-1,11-dioxy-2-naphthacenecarboxamide;abramycin;bio-tetra;bristaciclinalpha;bristacycline

Related categories

Antibiotics;Synthesis;Compounds:APIs;Small Molecule Inhibitors,Natural Products;References;Veterinary Drug APIs;APIs Intermediates-APIs;APIs;Tetracyclines;Other Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Peptide Synthesis /Antibiotics; microbial metabolites; pharmaceutical raw materials; small molecule inhibitors; reference substances; veterinary drug raw materials; medical raw materials; pharmaceutical impurities and intermediates; pesticides; antibiotics; pharmaceutical raw materials; raw materials; pharmaceuticals, pesticides and dye intermediates; chemical reagents ;Chemical Materials;Technical Intermediates;Reagents;General Biochemical Reagents-Antibiotics;Antibiotic Explorer;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics T-ZAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;Tetracyclines;Inhibitors

Introduction

Tetracycline is an antibiotic biosynthesized by dehalogenation catalyzed by chlortetracycline with low toxicity. It has been used clinically since 1948. It is a broad-spectrum bacteriostatic agent with bactericidal effect at high concentrations. In addition to common Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria, most of the rickettsia, mycoplasma, chlamydia, atypical mycobacteria, spirochetes are also sensitive to this product. The effect of this product on Gram-positive bacteria is better than that of Gram-negative bacteria, but Enterococcus is resistant to it.

Chemical properties

Use

●  Tetracycline can be used as the first choice or optional drug for the treatment of the following diseases:
(1) Rickettsial diseases, including epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus, rickettsial pneumonia and Q fever;
(2) Mycoplasma infection such as mycoplasma pneumonia, urethritis caused by Ureaplasma urealyticum, etc.;
(3) Chlamydia infection, including Chlamydia pneumoniae pneumonia, psittacosis, venereal lymphogranuloma and Chlamydia trachomatis infection;
(4) Relapsing fever caused by relapsing thermospira;
(5) Brucellosis (need to be used in combination with aminoglycosides);
(6) Cholera;
(7) Tularemia caused by Tularemia tularensis;
(8) Plague caused by Yersinia pestis.

●  Tetracyclines can also be used in the treatment of tetanus, gas gangrene, yaws, syphilis, gonorrhea, non-gonococcal urethritis, and leptospirosis that are allergic to penicillin antibiotics.

●  It can also be used for the treatment of acne with significant inflammatory response.

Team Presentation