CAS number：137-16-6
molecular formula：C15H28NO3.Na
molecular weight：293.38
EINECS number：205-281-5

English synonyms

n-methyl-n-(1-oxododecyl)glycinesodiumsalt;N-LAURYLSARCOSINE,SODIUMSALT;N-LAUROYLSARCOSINENA-SALT;N-LAUROYLSARCOSINESODIUMSALT;N-LAUROYLSARCOSINESODIUMSALTHYDRATE;GARDOL;LAUROYLSARCOSINE,SODIUMSALT;N-Methylglycinol

Related categories

Daily chemical raw materials; daily chemicals; organic acids; organic chemicals; organic chemical raw materials; flavors and fragrances; reagents; biochemical reagents; surfactants; detergents; proteomics; solvents; pharmaceutical raw materials; cosmetic raw materials; daily chemicals; Biochemical reagents-amino acids; chemical raw materials; pharmaceutical raw materials; pharmaceuticals, pesticides and dye intermediates; biochemicals; chemical products-organic chemicals; cosmetic raw materials-functional raw materials; food additives;organicchemicals;HairCare;OralCare;SkinCare;AminoACIDSSERIES;AnionicSurfactants;Carboxylate(Surfactants);FunctionalMaterial;Surfactants;Biochemistry;NonionicSurfactants(forBiochemistry);Surfactants(forBiochemistry);AdditionalAnionicDetergentsDetergents;Anionic;Detergents;DetergentsAtoZ;CosmeticIngredients&Chemicals;detergent; ;Organic intermediates;Others;Organic raw materials;Biological buffer series

Introduction

Sodium lauroyl sarcosinate, the English name is SODIUMLAUROYLSARCOSINATE, alias: sodium lauroyl-N-methylglycine, sodium lauroyl-N-methylglycinate. The main functions of sodium lauroyl sarcosinate in cosmetics and skin care products are antistatic, foam booster, detergent , and surfactant. The risk factor is 3. It is relatively safe and can be used with confidence. Generally, it has no effect on pregnant women. Sodium sarcosinate is not acne-causing. The FDA has approved sodium lauroyl sarcosinate as a direct food additive, and CIR allows it to be used in rinse-off products and leave-on products at a concentration of not more than 5%.

Chemical properties

Use

●  Sodium lauryl sarcosinate is an amino acid surfactant. In addition to its excellent surface activity, it also has the characteristics of antibacterial and bactericidal properties, corrosion and rust inhibition, and good biodegradability. Therefore, it is widely used in detergents and cosmetics. , food and beverage, metal rust, mineral flotation, pesticides and biomedicine and many other fields.

●  Biochemical Research. Anionic surfactants. Hexokinase inhibitors. Anionic detergent. Isolation of Yeast  RNA. It can be used for RNA and DNA isolation, as a solubilizer in cell purification, as an additive when separating DNA from human serum, and it can also increase the nitrogen-fixing ability of legume rhizobia by adding this product. It also has many applications in immunochemistry.

●  An anionic surfactant. Since it does not generate excessive foam, it can be used for cell lysis in RNA extraction protocols.

●  Relevant scholars have established an analytical method for the determination of sodium lauryl sarcosinate by gas chromatography. Using dodecanedicarboxylic acid as internal standard, the sample reacted with boron trifluoride methanol solution to generate methyl ester compound. Using HP-5 chromatographic column as analytical column and FID as detector, the internal standard method was used for quantification.

Production method

●  Synthesis of lauroyl chloride: add a certain amount of lauric acid in a dry three-necked flask equipped with a reflux condenser, heat and melt, control the temperature at 60-70 e, slowly add phosphorus trichloride dropwise under full stirring, and react for 2 h. The layers were left to stand, and the phosphorous acid in the lower layer was removed to obtain the upper layer of lauroyl chloride.

●  Synthesis of N-lauroyl sarcosine: add a certain amount of sodium sarcosinate solution and solvent tetrahydrofuran to a four-necked flask with an electric stirrer and a reflux condenser, and add lauroyl chloride and hydrogen dropwise by  under stirring. Sodium oxide aqueous solution, the pH value of the reaction system is controlled within the range of 9~11, after the dropwise addition, the reaction is continued for 3h to recover the solvent, and the pH value is adjusted to 1~2 with dilute acid to convert the sodium N-lauroyl sarcosinate into insoluble N-lauroyl sarcosine in water, so as to be separated from water-soluble inorganic salt impurities. The product was extracted with ether, the upper oil layer was washed with water until neutral, dried over anhydrous sodium sulfate, evaporated to remove the solvent, and recrystallized with petroleum ether to obtain white needle-like crystals.

●  The aqueous solution of sarcosine is prepared by adding sodium hydroxide to react with lauroyl chloride under alkaline conditions.

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