CAS number：9004-65-3
molecular formula：C3H7O
molecular weight：59.08708
EINECS number：618-389-6

English synonyms

hpmcd;hydroxylpropylmethylcellulose;Hydroxymethylpropylcellulose;isoptoalkaline;isoptoplain;isoptotears;methocele,f,k;HydroxypropylMethylCellulose(Hpmc)

Related categories

APIs; pharmaceutical raw materials; organic chemicals; carbohydrates; pharmaceutical excipients; chemical raw materials-1; thickeners; inorganic chemical raw materials; chemical products-organic chemicals; excipients; food additives; thickeners and gelling agents; non-ionic surfaces Active agents; industrial surfactants; chemical auxiliary agents; biochemical reagents; pharmaceutical intermediates; pharmaceutical excipients; chemical reagents; organic chemical raw materials; raw material intermediates - APIs; biochemical reagents - separation materials and consumables;NaturalPolymers;Cellulose;PolymerScience;CarbohydratesH-LBiochemicalsandReagents;Carbohydrates;CarbohydratesAto;Polysaccharide;DynamicSieving;CapillaryElectrophoresis;Oligosaccharide;AtoZBooksandSoftwareTitles;BiotechnologybooksBooksandSoftware ;BooksandSoftware;C;Labware;CapillaryZoneElectrophoresis;MaterialsScience;NaturalPolymers;PolymerScience;Polymers;OtherAPIs;propyleneglycolether;Thickeningagent;pharmaceuticalrawmaterialorintermediates;thickener,binders;Imidazoles,Homopiperidines;fine chemical materials;chemical intermediates industrial raw materials; Chemical raw materials; Tablet candy accessories; Bulk goods; Daily chemicals; Cell-cell lines; General biochemical reagents-Bioseparation reagents; Chemical industry; 3

Introduction

Hydroxypropyl methylcellulose is the propylene glycol ether of methylcellulose, in which the hydroxypropyl and methyl groups are combined with the anhydrous glucose ring of cellulose through ether bonds, and it is white to off-white cellulose powder or granules, with Similar cold water solubility and hot water insoluble properties as methyl cellulose. The solubility in organic solvents is better than that in water. It can be dissolved in anhydrous methanol and ethanol solutions, and can also be dissolved in organic solvents such as chlorinated hydrocarbons and ketones. Soluble in water, its aqueous solution has surface activity, forms a thin film after drying, undergoes reversible transformation from sol to gel in turn after heating and cooling. It can be used alone or in combination with other emulsifiers and stabilizers in cold drinks. The maximum dosage in cold drinks is 1%. In recent years, it has been widely used in petrochemical, papermaking, leather, textile printing and dyeing, medicine, food, cosmetics and other industries, as a dispersant, thickener, adhesive, excipient, capsule, oil-resistant coating and filler, etc.

Chemical properties

A propylene glycol ether of methylcellulose in which both the hydroxypropyl and methyl groups are bound to the anhydroglucose ring of cellulose by ether linkages. Different types of products have different ratios of methoxy and hydroxypropyl content. White to off-white fibrous powder or granules. Soluble in water and some organic solvents. Insoluble in ethanol, the aqueous solution has surface activity, forms a thin film after drying, undergoes a reversible transformation from sol to gel in turn after heating and cooling.

Use

●  Thickener; Stabilizer; Emulsifier; Gelling agent; Suspending agent.

●  Used as a synthetic resin dispersant, paint molding agent, and thickener

●  This product is used as thickener, dispersant, binder, emulsifier and stabilizer in the textile industry. It is also widely used in synthetic resin, petrochemical, ceramics, paper, leather, medicine, food, cosmetics and other industries.

●  Used in synthetic resins, petrochemicals, ceramics, papermaking, leather, textile printing and dyeing, medicine, food, cosmetics and other daily chemicals, as dispersants, thickeners, binders, excipients, capsules, oil-resistant coatings and filler etc.

Production method

●  Treat the refined cotton cellulose with lye at 35-40°C for half an hour, press it, crush the cellulose, and age it properly at 35°C, so that the average degree of polymerization of the obtained alkali fiber is within the required range. Put the alkali fiber into the etherification kettle, add propylene oxide and methyl chloride in sequence, and etherify at 50-80°C for 5 hours, the maximum pressure is about 1.8MPa. The reaction product is post-treated (neutralization with hydrochloric acid, iron removal with oxalic acid, washing, drying). Raw material consumption quota cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloric acid 30kg/t, oxalic acid 50kg/t.

●  Soak 100kg of refined short cotton linters in 45% lye at a temperature of 35-40°C for 0.5-1.0 hours, then take them out and press them. When the weight is 2.7 times that of cotton wool, stop pressing. Carry out crushing and loosening. Aged at 35°C for 16h. Put the above-mentioned aged alkali fibers into the reaction kettle, add methyl chloride and propylene oxide in turn, react at 80°C and pressure of 1.8MPa for 5-8 hours, then add appropriate amount of hydrochloric acid and oxalic acid to wash the materials in hot water at 90°C , to expand the volume. Dehydrate in a centrifuge. Wash until neutral, and when the water content in the material is lower than 60%, dry it with a hot air flow at 130°C until the water content is below 5%. Finally crushed through a 20-mesh sieve to obtain the finished product.

●  It is prepared from cellulose, methyl chloride and ethylene oxide.

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