CAS number：90045-36-6
molecular formula：
molecular weight：
EINECS number：289-896-4

English synonyms

24/6 GINKGO BILOBA EXTRACT 24/6;Ginkgo biloba leaves tea bag cut;Ginkgo biloba Ext.Ginkgolic acid max 5ppm;Ginkgo biloba Extract 24/6 5ppm (HPLC);GinkgoBilobaExtract26/6WaterSoluble;GINKGOBILOBAEXTRAKT;GINKGOBILOBA,STANDARDIZEDEXTRACT,POWDER;GINKGO BILOBA LEAF EXTRACT

Related categories

Pharmaceutical raw materials; plant extracts; pharmaceutical intermediates; plant extracts; nutrition fortifiers; cosmetic raw materials - whitening agents; chemical intermediates; pharmaceutical excipients; other 100% natural extracts; raw materials; Nutritional Supplements;Beauty;plant extract;Nutritional Ingredients;cosmetic;functional additives chemical raw materials;main recommended products;animal and plant extracts;cosmetic raw materials;proportional extracts;extracts;standard extracts;APIs

Introduction

Ginkgo biloba extract is the dry leaf extract of Ginkgo biloba plant Ginkgo biloba (Ginkgobiloba L.). The main components are flavonoids and terpene lactones. It has a variety of health care functions and is widely used in food and cosmetics.

Chemical properties

Use

●  Food and health products industry
The flavonoids in Ginkgo biloba have antioxidant properties and can be added to oils and cakes as antioxidants. The total flavonoids are mostly yellow and have wide solubility, both water-soluble and fat-soluble, so the total flavonoids can play a role in coloring. agent effect. Ginkgo biloba is processed into ultrafine powder and added to food. Ginkgo biloba leaves are superfinely pulverized and added to cakes, biscuits, noodles, candy and ice cream at 5% to 10%, and then they can be processed into ginkgo biloba food with health-care effects.
Ginkgo biloba extract is used as a food additive in Canada, and has been approved as an over-the-counter drug in Germany and France. Ginkgo biloba is listed in the United States Pharmacopoeia (24th Edition), and Ginkgo biloba extract is available as a dietary supplement in the United States. There are more than 30 kinds of ginkgo products in the world, and the main dosage forms include: ginkgo leaf, ginkgo oral liquid, ginkgo lactone injection, ginkgo damole injection, ginkgo ketone ester dropping pills, compound ginkgo leaf granules, ginkgo leaf extract, etc. . From 2009 to 2011, the sales and DDDs of Ginkgo biloba preparations ranked among the top three commonly used traditional Chinese medicines for cardiovascular diseases.
Ginkgo biloba contains a small amount of proanthocyanidins and urushiolic acids, which are toxic to the human body. When using ginkgo leaves as raw materials to process food, special treatment is required to reduce the content of proanthocyanidins and urushiolic acids. However, within the currently used dose range, there is no acute and chronic toxicity and no teratogenic effects. The Ministry of Health has approved Ginkgo biloba extract as a new food additive in 1992. In recent years, the total flavonoids of Ginkgo biloba have been widely used in the food industry, and the research and development of Ginkgo biloba has broad prospects.

●  Daily chemical industry
The combination of Ginkgo biloba extract and skin absorption enhancer can also prevent irritation caused by adhesives used in external ointments and patches, such as creams, ointments, creams, sols and plaster tapes. The skin care products containing GBE on the market now mainly include anti-aging cleanser, body wash, lipstick, eye cream, etc. GBE can also be used in the production of hair growth and hair care products. Chen Yan and others even added Ginkgo biloba extract to toothpaste, and according to their research, it has a certain anti-caries effect.

Production method

According to incomplete statistics, the current international standard Ginkgo biloba extract is EGb761 produced according to the German Schwabe patented process. The appearance is brown powder with a slight ginkgo leaf fragrance. Ginkgo biloba extract is a product extracted from the leaves of Ginkgo biloba L. as raw material. Commercial extracts are usually standardized to contain 24% of flavonol glycosides and 6% of ginkgo terpene lactones.
There are many methods reported in the literature on the production process of Ginkgo biloba extract, mainly including acetone extraction-lead salt precipitation method, ethanol extraction-macroporous resin adsorption separation method, supercritical carbon dioxide extraction method, alcohol extraction-extraction-chromatographic separation method, etc. The most widely used method in China is the ethanol extraction-resin separation method.
At present, the most widely used method at home and abroad is the organic solvent extraction method. Since other organic solvents are toxic or volatile, ethanol is generally used as the extractant. Experiments by Zhang Yonghong and others showed that the best conditions for extracting flavonoids from Ginkgo biloba leaves are 70% ethanol as the extract, the extraction temperature is 90°C, the material-liquid ratio is 1:20, the extraction times are 3 times, and each reflux is 1.5h.

1. Ethanol extraction-macroporous resin adsorption separation method
Remove impurities and mildew leaves, wash, chop, extract with 70% ethanol reflux, separate the extract, filter, recover ethanol under reduced pressure, remove slag by high-speed centrifugation, add appropriate amount of pure water to dilute, add to macroporous adsorption The resin column is eluted with water until the eluent is clear and light in color, and then eluted with a certain concentration of ethanol, the eluent is collected, concentrated under reduced pressure, and dried in vacuo.

2. Acetone extraction-lead hydroxide precipitation method
Ginkgo biloba leaves were extracted with 60% acetone, filtered after cooling, the extract was extracted with carbon tetrachloride, butanone was added and mixed, the acetone-butanone phase was separated and separated out, and solid ammonia sulfate was added to the ketone phase and stirred, and the solid was filtered off. substance, evaporate the filtrate under reduced pressure to a concentration of 20%-60% solid content, and dilute with 50% denatured ethanol to a concentration of 10% solid content. The lead hydroxide suspension was added and the precipitate was filtered off. The filtrate is concentrated under reduced pressure to half the volume, then ammonium sulfate and butanone are added to the concentrated solution under stirring, and the butanone-ethanol phase is separated out after the stirring; the butanone-ethanol phase is separated from the water phase, and then in the water phase Add butanone, stir, separate out butanone-ethanol phase, and combine into the above-mentioned butanone-ethanol phase. Add ammonium sulfate under stirring, separate the precipitated water phase after mixing, dry the butanone-ethanol phase with sodium sulfate, evaporate to dryness under reduced pressure, dissolve the denatured viscous residue with denatured ethanol, stand for 12 hours to separate the precipitated precipitate, reduce Evaporate under pressure and dry under vacuum.

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