Details
Ropivacaine hydrochloride, cas 132112-35-7, molecular formula C17H26N2O.ClH.H2O. The compound is a chiral molecule, it can be optically active, and the ratio of the two chiral isomers is about 1:1. White crystal or crystalline powder, its crystal morphology can be observed through a microscope. It may sometimes have yellow or brown spots as the compound oxidizes in the air. The solubility in water is 27.5mg/mL at 20°C, and the solubility is better when the pH is 4.5-5.5. In addition, it also has good solubility in ethanol and methanol. A cationic compound that exists as a salt in water. This is due to the attraction between a positively charged amine group and a negatively charged chloride ion in the Ropivacaine molecule. It is a local anesthetic commonly used for pain relief and anesthesia during surgery.

Ropivacaine hydrochloride is a local anesthetic often used for pain relief and anesthesia during surgery.

Specifications 

Melting point: 267-269°C

Specific rotation: D20 -7.28° (c=2inwater)

Storage conditions: 2-8°C

Solubility: Soluble in H2O: 5 mg/mL, clear

Appearance: Powder

Color: White to off-white

Common side effects of ropivacaine hydrochloride include hypotension, nausea, bradycardia, anxiety, and decreased sensation.

Biological activity: Ropivacaine HCl (LEA-103) is an anesthetic that blocks impulse transmission along nerve fibers by reversibly inhibiting sodium ion influx.

Target IC50: sodium ion influx IC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)

In vitro studies have shown that Ropivacaine HCl is a local anesthetic. Ropivacaine HCl induces nerve block by reversibly inhibiting sodium ion flow in nerve fibers. The pKa of Ropivacaine HCl is ~8.2. Ropivacaine HCl has the potential to induce cardiovascular and CNS toxicity at high plasma concentrations.